Nuclear Factor I-C Is Essential for Odontogenic Cell Proliferation and Odontoblast Differentiation during Tooth
نویسندگان
چکیده
From the Department of Oral Histology-Developmental Biology, Dental Research Institute, Conservative Dentistry, **Oral & Maxillofacial Surgery, and Tooth Bioengineering National Research Lab, School of Dentistry, Seoul National University, Seoul 110-749, Korea and the Department of Biochemistry and the Program in Neuroscience, School of Medicine and Biomedical Science, and the Department of Oral Biology, School of Dental Medicine, State University of New York at Buffalo, Buffalo, New York 14214-3092
منابع مشابه
Nuclear factor I-C is essential for odontogenic cell proliferation and odontoblast differentiation during tooth root development.
Our previous studies have demonstrated that nuclear factor I-C (NFI-C) null mice developed short molar roots that contain aberrant odontoblasts and abnormal dentin formation. Based on these findings, we performed studies to elucidate the function of NFI-C in odontoblasts. Initial studies demonstrated that aberrant odontoblasts become dissociated and trapped in an osteodentin-like mineralized ti...
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Nuclear factor I-C (NFI-C) plays a pivotal role in various cellular processes such as odontoblast and osteoblast differentiation. Nfic-deficient mice showed abnormal tooth and bone formation. The transplantation of Nfic-expressing mouse bone marrow stromal cells rescued the impaired bone formation in Nfic-/- mice. Studies suggest that NFI-C regulate osteogenesis and dentinogenesis in concert wi...
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Transforming growth factor-β1 (TGF-β1) signaling plays a key role in vertebrate development, homeostasis, and disease. Nuclear factor I-C (NFI-C) has been implicated in TGF-β1 signaling, extracellular matrix gene transcription, and tooth root development. However, the functional relationship between NFI-C and TGF-β1 signaling remains uncharacterized. The purpose of this study was to identify th...
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